On combining estimates of relative potency in bioassay

1 September 1962

journal article
research article
Published by Cambridge University Press (CUP) in Epidemiology and Infection

Vol. 60 (3) , 379-385
https://doi.org/10.1017/s0022172400020490

Abstract

Biological assays based on a quantitative response in particular (e.g. hormone assays) typically involve the estimation of (log) relative potency (=M) with respect to some standard preparation on the basis of one or more symmetrical determinations usually at equally spaced (log) dose intervals. It is the purpose of this paper to consider further statistical aspects of estimates ofM, and especially confidence limits forMbased on a combination of separate assays. These are given as examples of tests of linear hypotheses. Two applications are given on the combining of quantitative bio-assay data.

Keywords

BIOLOGICAL ASSAY

This publication has 4 references indexed in Scilit:

Some Problems in Interval Estimation
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1954
Biological assays with special reference to biological standards
Epidemiology and Infection, 1950
ON AN IMPORTANT CLASS OF STATISTICAL HYPOTHESES
Biometrika, 1935
On an Important Class of Statistical Hypotheses
Biometrika, 1935