Effect of Hydrochloric Acid on Iron Absorption

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Abstract
To elucidate the role of gastric acid in iron absorption, six normal subjects and six with pernicious anemia were given ferric iron, mixed with ascorbate to form a chelate that remained soluble after alkalinization with sodium hydroxide, and ferric iron that had been precipitated with sodium hydroxide before the addition of ascorbate and remained insoluble. Either 59Fe or 55Fe was added to the iron preparations, and the absorption of 59Fe was measured with a whole-body counter.