Lung-to-Liver Migration of Schistosomes in the Laboratory Mouse

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Abstract
Summary The relative number and character of the schistosomules of Schistosoma mansoni, Heterobilharzia americana and Schistosomatium douthitti in the lungs, pleural cavities, liver, mesenteric vessels, heart, and diaphragm of the white mouse were determined at daily intervals during the early period of infection. The hypothesis that the migration from lungs to liver occurs entirely or mainly within the blood stream was not supported. Significant numbers of larvae were found in the pleural spaces, and there was evidence of a direct migration through the pleura, diaphragm, and Glisson's capsule to the liver parenchyma and thence to the portal vessels.

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