A DOUBLE-BLIND COMPARISON OF NIFLUMIC ACID WITH PHENYLBUTAZONE, OXYPHENYLBUTAZONE AND PLACEBO IN THE TREATMENT OF OSTEOARTHROSIS

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Abstract
In this double-blind trial, 42 patients received niflumic acid, 20 phenylbutazone, and 21 oxy-phenylbutazone while 17 were on placebo for eight weeks. All patients (100 cases) had osteoarthrosis of hips and/or knees. Subjective manifestations (overall effectiveness, improvement of pain and joint mobility), as well as objective signs (maximum intermalleolar distance and range of knee-joint flexion), showed significant improvement in those receiving any of the three drugs compared with those on placebo, but there was no significant difference between the therapeutic efficacy of the three drugs. Of the three drugs, niflumic acid produced the least number of side-effects. No significant change occurred in the laboratory data except that occult blood in stools became positive in one patient on phenylbutazone and three on oxyphenylbutazone. One of the latter group developed frank melaena.

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