Malignant giant cell tumour of the larynx

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Abstract
This case belongs to the group of primary human giant cell tumors of the larynx. It is the 10th case described in the international literature. Although there is a striking similarity between these tumors and giant cell bone tumors, their distribution between the sexes is different. Of the 10 known cases of giant cell tumors of the larynx it appears that only this case, in spite of the absence of genuine sarcomatous stroma, was considered to be malignant from the beginning because of marked cellularity, the unequal size of stromal cells and relatively numerous mitoses. In several locations, the stromal cells closely surrounded the giant cells which were small and had few nuclei. Its subsequent evolution, particularly metastases to the skin, justifies the initial histological diagnosis. Giant cell tumors of the larynx should be treated conservatively preserving, as far as possible, laryngeal function. Surgical removal of the entire larynx should be a last resort when radiotherapy and conservtive operations have failed.

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