Analgesic Activity of Oral Naproxen in Patients with Postoperative Pain

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Abstract
Oral naproxen in doses of 100, 200 and 400 mg was compared with oral meperidine in doses of 25 and 75 mg, in a double-blind, single-dose, completely-randomized study of patients with postoperative pain. One hundred patients were studied, twenty for each of the five treatments. The patients1 subjective pain scores were recorded by an observer for four hours after administration of the treatment. Dose-effect trends were present with both naproxen and meperidine. Naproxen 400 mg performed the best of all treatments in the study; on pain-score measurements it was significantly superior to meperidine 25 mg; and in terms of the number of patients requiring re-medication for pain during the four-hour observation period, significantly fewer patients failed on naproxen 400 than on naproxen 100 mg. No appreciable excess of side effects occurred with naproxen.

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