Identification of S-(2,5-dihydroxyphenyl)-cysteine and S-(2,5-dihydroxyphenyl)-N-acetyl-cysteine as urinary metabolites of acetaminophen in the mouse. Evidence for p-benzoquinone as a reactive intermediate in acetaminophen metabolism
- 1 January 1988
- journal article
- research article
- Published by Elsevier in Chemico-Biological Interactions
- Vol. 68 (1-2) , 85-98
- https://doi.org/10.1016/0009-2797(88)90008-7
Abstract
No abstract availableKeywords
This publication has 20 references indexed in Scilit:
- Hydrolysis of the model carcinogen N-(pivaloyloxy)-4-methoxyacetanilide: involvement of N-acetyl-p-benzoquinone imineJournal of the American Chemical Society, 1986
- Detection and identification of sulfhydryl conjugates of p-benzoquinone in microsomal incubations of benzene and phenolChemico-Biological Interactions, 1983
- Determination of acetaminophen metabolites in urine by liquid chromatography/electrochemistryAnalytical Biochemistry, 1982
- Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophenJournal of Medicinal Chemistry, 1982
- Analysis of acetaminophen metabolites in urine by high-performance liquid chromatography with UV and amperometric detectionJournal of Chromatography B: Biomedical Sciences and Applications, 1982
- Conversion of the prosthetic moieties of glutathione pathway conjugates to the correspondingS- acetatesJournal of Mass Spectrometry, 1982
- Acetaminophen-induced hepatotoxicityLife Sciences, 1981
- Comparative electron impact, chemical ionization and field desorption mass spectra of some thioether metabolites of acetaminophenJournal of Mass Spectrometry, 1981
- Lack of evidence for N-hydroxyacetaminophen as a reactive metabolite of acetaminophen in vitroBiochemical Pharmacology, 1980
- Evidence for the involvement of N-ACETYL-p-quinoneimine in acetaminophen metabolismBiochemical Pharmacology, 1979