Hemoglobin istanbul: substitution of glutamine for histidine in a proximal histidine (F8(92)β)
Open Access
- 1 September 1972
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 51 (9) , 2380-2387
- https://doi.org/10.1172/jci107050
Abstract
A presumably spontaneous mutation has resulted in the formation of Hemoglobin (Hb) Istanbul in which glutamine is substituted for histidine in the proximal position of the beta-chain (F8(92)). The anemia and other physiological effects that occur in the presence of Hb Istanbul were much ameliorated by splenectomy. Hb Istanbul is a relatively unstable molecule which produces a rather moderate case of "unstable hemoglobin hemolytic anemia."In the determination of structure, a method of preferential cleavage of an aspartyl-proline bond at residues 99-100 of the beta-chain was used.Keywords
This publication has 20 references indexed in Scilit:
- Three-dimensional Fourier Synthesis of Horse Oxyhaemoglobin at 2.8 Å Resolution: The Atomic ModelNature, 1968
- Hemoglobin Kansas, a Human Hemoglobin with a Neutral Amino Acid Substitution and an Abnormal Oxygen EquilibriumJournal of Biological Chemistry, 1968
- Studies on the heterogeneity of hemoglobinJournal of Chromatography A, 1968
- Abnormal human haemoglobins: Separation and characterization of the α and β chains by chromatography, and the determination of two new variants, Hb chesapeake and Hb J (Bangkok)Journal of Molecular Biology, 1966
- On the Aminoethylation of ProteinsJournal of Biological Chemistry, 1966
- A simple method for the quantitation of haemoglobin-A2 by starch gel electrophoresisClinica Chimica Acta; International Journal of Clinical Chemistry, 1965
- An Improved Gradient for Ion Exchange Chromatography of Peptides on Dowex-1.Analytical Chemistry, 1965
- The gel-filtration behaviour of proteins related to their molecular weights over a wide rangeBiochemical Journal, 1965
- Studies on the heterogeneity of hemoglobinJournal of Chromatography A, 1965
- Estimation of the molecular weights of proteins by Sephadex gel-filtrationBiochemical Journal, 1964