Conformational analysis by carbon-13 nuclear magnetic resonance spectroscopy. Part I. Hexahydro-3H-oxazolo[3,4-a] pyridines
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 1,p. 51-54
- https://doi.org/10.1039/p29750000051
Abstract
Compraison of the C(3), C(1), and C(8a) chemical shifts in hexahydro-3H-oxazolo [3,4-a] pyridine with those in methyl substituted derivatives suggests its existence in solution at n.m.r. probe temperature as a cistrans equilibrium mixture containing 73–78% of the trans-fused conformation; 13C–H coupling constants involving the C(3) protons are dependent upon the orientation of adjacent heteroatom lone pairs.Keywords
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