Nerve growth factor: a neurotrophin with activity on cells of the immune system
- 15 May 1999
- journal article
- review article
- Published by Wiley in Microscopy Research and Technique
- Vol. 45 (4-5) , 285-291
- https://doi.org/10.1002/(sici)1097-0029(19990515/01)45:4/5<285::aid-jemt12>3.0.co;2-3
Abstract
Numerous studies published in the last two decades provide evidence that nerve growth factor (NGF), a polypeptide originally discovered because of its neurotrophic activity, acts on a variety of cells of the immune system, including mast cells, eosinophils, and B and T lymphocytes. NGF has been shown to increase during inflammatory responses, autoimmune disorders, parasitic infections, and allergic diseases. Moreover, stress, which is characterized also by activation of a variety of immune cells, causes a significant increase in basal plasma NGF levels. Recently published studies reveal that hematopoietic progenitor cells seem to be able to produce and/or respond to NGF. We report these data and discuss the hypothesis of the possible implication of NGF on the functional activities of immune cells. Microsc. Res. Tech. 45:285–291, 1999.Keywords
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