Smurfing at the Leading Edge
- 5 December 2003
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 302 (5651) , 1690-1691
- https://doi.org/10.1126/science.1092874
Abstract
Cell biologists are only now beginning to unravel how cells maintain their polarity and how this polarity contributes to cell migration. In their Perspective, Jaffe and Hall discuss new research ( Wang et al.) describing how ubiquitination and degradation of Rho GTPase (which is an important regulator of the actin cytoskeleton) results in spatial restriction of Rho at the rear of the cell, an essential step in cellular migration.Keywords
This publication has 10 references indexed in Scilit:
- Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for DegradationScience, 2003
- Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor DegradationCell, 2003
- Spatial and Temporal Analysis of Rac Activation during Live Neutrophil ChemotaxisCurrent Biology, 2002
- Cell polarity: Par6, aPKC and cytoskeletal crosstalkCurrent Opinion in Cell Biology, 2002
- CNF1 Exploits the Ubiquitin-Proteasome Machinery to Restrict Rho GTPase Activation for Bacterial Host Cell InvasionCell, 2002
- Proteasomal Degradation of Cytotoxic Necrotizing Factor 1-Activated RacInfection and Immunity, 2002
- ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblastsThe Journal of cell biology, 2002
- Themes and variations on ubiquitylationNature Reviews Molecular Cell Biology, 2001
- Rhoa Function in Lamellae Formation and Migration Is Regulated by the α6β4 Integrin and Camp MetabolismThe Journal of cell biology, 2000
- Rho GTPases and the Actin CytoskeletonScience, 1998