Region-Specific Corpus Callosum Atrophy Correlates With the Regional Pattern of Cortical Glucose Metabolism in Alzheimer Disease

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Abstract
THREE LINES of evidence support the notion of Alzheimer disease (AD) as a progressive neocortical disconnection syndrome.1-3 Neuropathological investigations3-6 find neurofibrillary tangles, a marker for cellular degeneration in AD, predominantly in large pyramidal neurons in cortical layers 3 and 5. These neurons give rise to long corticocortical connections within and between the hemispheres.7-9 They are detected in a clustered organization within the cortex of the primate brain.10 There is evidence2 for a similar clustered pattern of β-amyloid deposits in AD that would specifically connect these hallmarks of pathology with the corticocortical projecting neurons.