Immunoglobulin G1 Antibody Response toHelicobacter pyloriHeat Shock Protein 60 Is Closely Associated with Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

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Abstract
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is related toHelicobacter pyloriinfection. Specifically, it has been pointed out that pathogenesis of MALT lymphoma involves the 60-kDa heat shock protein (hsp60). To investigate humoral immune responses to theH. pylorihsp60 in patients with gastroduodenal diseases and patients with MALT lymphoma, the hsp60 ofH. pyloriwas expressed with a glutathioneS-transferase fusion protein and was purified (recombinant hsp60). Sera were obtained fromH. pylori-positive patients with gastroduodenal diseases (MALT lymphoma,n= 13; gastric ulcer,n= 20; duodenal ulcer,n= 20; gastritis,n= 20) and fromH. pylori-negative healthy volunteers (n= 9). Sera from patients with MALT lymphoma were also obtained at two times: before and after eradication therapy. Antibodies to hsp60 andH. pyloriwere assessed by enzyme-linked immunosorbent assay. The levels of immunoglobulin G (IgG) antibodies to the hsp60 ofH. pylori-positive patients with gastroduodenal diseases were significantly elevated compared to those in the controls. The levels of IgG1 antibodies to hsp60 were elevated and correlated with the levels of anti-H. pyloriantibodies in patients with MALT lymphoma. Humarol immunity against hsp60 may be important and relevant to gastroduodenal diseases induced byH. pyloriinfection.

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