Selective Monoformylation Of 1,3-Diaminopropane Derivatives
- 1 June 1999
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 29 (11) , 1819-1833
- https://doi.org/10.1080/00397919908086172
Abstract
A general procedure for regiospecific construction of N-aryl-N'-formyl-1,3-diaminopropanes 2 (R=H) by selective monoformylation of N-(3-aminopropyl)arylamines 1 is described. Compounds 1 are readily obtained with high yields by aminolysis of 3-bromopropylamine hydrobromide with aromatic amines. The present synthetic strategy was extended to the synthesis of other N-acyl-N-aryl-1,3 -diaminopropanes.Keywords
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