The 5′‐CA DNA‐sequence preference of daunomycin
- 25 January 1988
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 227 (2) , 103-106
- https://doi.org/10.1016/0014-5793(88)80877-9
Abstract
The DNA-sequence specificity of daunomycin was investigated by DNase I footprinting and an E. coli RNA polymerase transcription-inhibition assay. The 5′-CA sequence was identified as being the highest affinity binding site, although other modest affinity (5′-GC, CG, CT, TC, AC) and poor affinity sites (5′-AA, AT, TA) were also observed. The preference of daunomycin for 5′-CA nucleotide sequence suggests that its biological activity may arise from association with the 5′-CA-containing sequences thought to be associated with genetic regulatory elements in eukaryotesKeywords
This publication has 23 references indexed in Scilit:
- Interactions between an anthracycline antibiotic and DNA: molecular structure of daunomycin complexed to d(CpGpTpApCpG) at 1.2-.ANG. resolutionBiochemistry, 1987
- Kinetics and sequence specificity of drug-DNA interactions: an in vitro transcription assayBiochemistry, 1986
- Nucleotide sequence binding preferences of nogalamycin investigated by DNase I footprintingBiochemistry, 1986
- Identification of the specific sites of interaction between intercalating drugs and DNAChemico-Biological Interactions, 1984
- Interactions of molecules with nucleic acids. VII. Intercalation and T·A specificity of daunomycin in DNABiopolymers, 1984
- Sequence specificity of drug-DNA interactionsLife Sciences, 1983
- TECHNOLOGICAL EXAMINATION OF LOW‐FIRED TERRACOTTA STATUES FROM AYIA IRINI, KEAArchaeometry, 1982
- DNA supercoiling: Another level for regulating gene expressionCell, 1981
- Escherichia coli deoxyribonucleic acid-dependent ribonucleic acid polymerase transcriptional pause sites on SV40 DNA F1Biochemistry, 1981
- Molecular structural effects involved in the interaction of anthracyclines with DNAChemico-Biological Interactions, 1979