Calcium Metabolism in Alzheimer’s Disease

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Abstract
Aluminium is present in senile plaques and in neurofibrillary tangle-bearing neurones in brains of cases of Alzheimer’s disease. Evidence linking aluminium absorption to calcium metabolism prompted a case-control study of physiological markers of calcium homeostasis in patients with Alzheimer’s disease. Mean plasma 25-hydroxyvitamin D concentration was lower in cases than in controls but no difference in median parathyroid hormone concentrations or other evidence of altered calcium metabolism was found. The difference in 25-hydroxyvitamin D concentrations may be secondary to differences in exposure to sunlight.