Effect of Pesticide Exposure on Human Microsomal Enzyme Induction
- 1 March 1982
- journal article
- research article
- Published by SAGE Publications in Human Toxicology
- Vol. 1 (2) , 155-158
- https://doi.org/10.1177/096032718200100208
Abstract
1 The antipyrine half-life, metabolic clearance rate and the apparent volume of distribution were measured in six subjects handling malathion. These results were compared with six appropriate controls.2 Occupational exposure of malathion in subjects reduced the antipyrine half-life from 9.18 ± 2.16 h in controls to 4.73 ± 1.65 h.3 It is concluded that malathion exposure increases the rate of antipyrine elimination, possibly by inducing the hepatic microsomal enzymes.Keywords
This publication has 4 references indexed in Scilit:
- Antipyrine kinetics in cannabis smokers.Published by Wiley ,1981
- Effect of intensive occupational exposure to DDT on phenylbutazone and cortisol metabolism in human subiectsClinical Pharmacology & Therapeutics, 1970
- Effect of environmental factors on drug metabolism: Decreased plasma half‐life of antipyrine in workers exposed to chlorinated hydrocarbon insecticidesClinical Pharmacology & Therapeutics, 1969
- THE FATE OF ANTIPYRINE IN MANThe Journal of Pharmacology and Experimental Therapeutics, 1950