Inhibition of histamine skin flare reaction following repeated topical applications of capsaicin
- 1 February 1990
- Vol. 45 (2) , 121-125
- https://doi.org/10.1111/j.1398-9995.1990.tb00469.x
Abstract
The intention was to clarify, experimentally, some of the clinical properties of capsaicin. The modulation of histamine-induced immediate inflammatory responses following subsequent topical applications of capsaicin was studied. A gradual dose-dependent reduction of the acute inflammatory reaction was observed after daily epicutaneous application of 1% capsaicin for 6 days. The modulation suggests that the small nerve fibres responsible for the neurogenic spread of the flare gradually become less excitable. After termination of capsaicin applications the flare returned to its initial value after 9 days. The recovery phase was longer than the inhibition phase, probably due to slow repletion of neuropeptides in the cutaneous nerve endings.Keywords
This publication has 23 references indexed in Scilit:
- Treatment of chronic postherpetic neuralgia with topical capsaicin: A preliminary studyJournal of the American Academy of Dermatology, 1987
- The effect of capsaicin application to a peripheral nerve on impulse conduction in functionally identified afferent nerve fibresBrain Research, 1983
- Capsaicin applied to peripheral nerve inhibits axoplasmic transport of substance P and somatostatinBrain Research, 1982
- Effects of capsaicin applied locally to adult peripheral nerve. II. Anatomy and enzyme and peptide chemistry of peripheral nerve and spinal cordPain, 1981
- Increase in tissue concentrations of histamine and 5-hydroxytryptamine following capsaicin treatment of newborn ratsLife Sciences, 1981
- Inhibition of Axon Reflex Vasodilatation by Topically Applied CapsaicinJournal of Investigative Dermatology, 1981
- Flare and Itch Induced by Substance P in Human SkinJournal of Investigative Dermatology, 1978
- The action of local anaesthetics on histamine releaseBiochemical Pharmacology, 1976
- The inhibitory effect of antiallergy drugs on allergen and histamine induced wheal and flare responseJournal of Allergy and Clinical Immunology, 1973