Overweight and Obesity as Determinants of Cardiovascular Risk

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Abstract
OBESITY COEXISTS with a variety of cardiovascular risk factors and has been related to greater cardiovascular risk in a variety of observational studies.1,2 Less well studied is the relation between categories of adiposity, the development of metabolic risk factors, and cardiovascular sequelae in a population setting, focusing on individuals with average weight for height.2,3 Such an approach requires data with repeated measures of weight, risk factor status, and cardiovascular disease (CVD) incidence. The long-term experience of the Framingham Heart Study cohort met these requirements and included up to 44 years of follow-up to study the relation between body mass index (BMI) and the development of CVD and intervening risk factors in middle-aged men and women.