Tumorigenesis in Mouse Skin: Inhibition by Synthetic Inhibitors of Proteases
- 18 September 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 169 (3951) , 1211-1213
- https://doi.org/10.1126/science.169.3951.1211
Abstract
Three synthetic inhibitors of proteases (tosyl lysine chloromethyl ketone, tosyl phenylalanine chloromethyl ketone, and tosyl arginine methyl ester) inhibit the tumorigenesis initiated in mouse skin by 7,12-dimethylbenz( a )anthracene and promoted by croton oil or its active principle, phorbol ester. These protease inhibitors, when applied directly to mouse skin, inhibit some of the irritant effects of the tumor promoter and are not toxic.Keywords
This publication has 8 references indexed in Scilit:
- Sensitive proteolytic enzyme assay using differential solubilities of radioactive substrates and products in biphasic systemsAnalytical Biochemistry, 1970
- Overgrowth Stimulating Factor Released from Rous Sarcoma CellsScience, 1970
- Polyinosinic-Polycytidylic Acid Inhibits Chemically Induced Tumorigenesis in Mouse SkinScience, 1970
- Studies on lysosomes—X: Effects of tumor-promoting agents upon biological and artificial membrane systemsBiochemical Pharmacology, 1968
- Chemical modification of papainArchives of Biochemistry and Biophysics, 1968
- Evidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from Nα-Tosyl-L-lysine*Biochemistry, 1965
- The Effect of Cortisone on Chemical Carcinogenesis in the Mouse SkinBritish Journal of Cancer, 1954
- An Experimental Study of the Initiating Stage of Carcinogenesis, and a Re-examination of the Somatic Cell Mutation Theory of CancerBritish Journal of Cancer, 1949