THE ACTION OF PHLORIZIN ON THE EXCRETION OF GLUCOSE, XYLOSE, SUCROSE, CREATININE AND UREA BY MAN

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Abstract
The minimum intravenous dose of phlorhizin required in man to produce complete phlorhizination (i.e., to raise the glucose clearance to xylose clearance) was in the neighborhood of 10-20 mgm. per kgm. 65 mgm. per kgm. did not raise the glucose clearance above the xylose clearance, and 59.4 mgm. per kgm. did not cause deviation between the xylose and sucrose clearances. Neither did the phlorhizin cause a significant rise in the xylose clearance as compared to control periods taken just before the administration of the drug. The largest dose given (65.0 mgm. per kgm.) exerted no significant depressive action on the ratio of creatinine: xylose clearance.

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