THE EVI-1 ZINC FINGER MYELOID TRANSFORMING GENE IS NORMALLY EXPRESSED IN THE KIDNEY AND IN DEVELOPING OOCYTES
- 1 September 1990
- journal article
- research article
- Vol. 5 (9) , 1419-1423
Abstract
Activation of the Evi-1 zinc finger gene is commonly associated with the transformation of murine leukemias and is involved in some cases of human AML involving rearrangements at chromosome 3q25. To determine the normal function of the gene, we have looked for expression in a variety of cell lines and tissues. The predominant sites of expression of the gene are in the kidney and ovary. In the kidney, expression is localized to the renal tubules in the corticomedullary junction. In the ovary, high levels of the Evi-1 protein are found in the cytoplasm of developing oocytes. The latter result suggests a potential role for the Evi-1 gene product in early oocyte development.This publication has 7 references indexed in Scilit:
- UNIQUE EXPRESSION OF THE HUMAN EVI-1 GENE IN AN ENDOMETRIAL CARCINOMA CELL-LINE - SEQUENCE OF CDNAS AND STRUCTURE OF ALTERNATIVELY SPLICED TRANSCRIPTS1990
- Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene.Molecular and Cellular Biology, 1990
- CLINICOPATHOLOGIC MANIFESTATIONS AND BREAKPOINTS OF THE T(3-5) IN PATIENTS WITH ACUTE NONLYMPHOCYTIC LEUKEMIA1989
- Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell linesCell, 1988
- Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors.Molecular and Cellular Biology, 1988
- Correlation of cell-surface phenotype with the establishment of interleukin 3-dependent cell lines from wild-mouse murine leukemia virus-induced neoplasms.Proceedings of the National Academy of Sciences, 1985
- A specific transcription factor that can bind either the 5S RNA gene or 5S RNA.Proceedings of the National Academy of Sciences, 1980