Effect of angiotensin‐converting enzyme inhibitor YS980 on prostaglandin synthesis in rabbit kidney medulla slices

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Abstract
The effect of YS980, an angiotensin-converting enzyme inhibitor, on the generation of medullary prostaglandins E2 and F2α was examined. At concentrations of 0.2 mm and below, YS980 enhanced prostaglandin F2α synthesis at the expense of prostaglandin E2. At concentrations of 0.4 mm or more, YS980 inhibited synthesis of both prostaglandins E2 and F2α markedly. These results suggest that YS980 has the potential to modulate prostaglandins E2 and F2α synthesis by the kidney and that this effect may represent some pharmacological action of the drug.