THE HEALING PROCESS OF GASTRIC ULCER IN MAN

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Abstract
-Healing changes were apparent in all except 5 of 30 gastric ulcers; the 5 were of the perforating type. The keystone of the healing factors was the granulation tissue plug first described by Mann in experimentally produced peptic lesions. Size of the ulcer was a significant factor in healing. Large ulcers heal with much more difficulty than small ones. In the former multiple granulation tissue plugs may form in the crater or at the margin of the lesions; this latter probably is a defense against marginal enlargement of the ulcer. Complete healing of a large ulcer by formation of multiple buds of granulation tissue was not observed. Epithelium at the margin of the lesions grew out as a single flat layer of cells and covered the granulation tissue mushroom in the excavation. Later the connective tissue contracted and formed a scar-filled defect covered by atypical epithelium.

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