Statistics of Kinetic Pathways on Biased Rough Energy Landscapes with Applications to Protein Folding
- 17 June 1996
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 76 (25) , 4861-4864
- https://doi.org/10.1103/physrevlett.76.4861
Abstract
Using path integrals, the statistics of kinetic pathways on a biased random energy landscape can be mapped on to the statistical mechanics of the random directed polymer. Using this, we make explicit the role of time scales in defining a protein folding pathway and the connections between thermodynamic glass transitions of the protein and the emergence of discrete kinetic pathways for folding.Keywords
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