Pharmacologic Advances in the Treatment of Schizophrenia

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Abstract
Although medications have dramatically improved the lives of many people with schizophrenia, treatment resistance remains a serious problem. Three quarters of patients with schizophrenia become ill before the age of 25. The manifestations of the disease include two types of symptoms — “positive” and “negative.” Positive symptoms are distortions of normal functioning. Distortion of perceptions may appear as hallucinations; distortion of inferential thinking may lead to delusions. Negative symptoms involve the loss of normal functioning — the loss of will, range of affect, pleasure, and fluency and content of speech. The intensity of these symptoms and the residual disability they . . .