INTERLABORATORY SURVEY OF ENZYMATIC ANALYSES .2. INTERMEDIATE STUDIES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 68  (1) , 142-152
Abstract
A set of 6 interrelated specimens was analyzed for creatinine, urea and 5 enzyme constituents [lactate dehydrogenase, creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase) by about 40 laboratories on 2 occasions. The results from each laboratory were subjected to linear regression analysis and the correlation coefficients, X and Y intercepts, and slopes were calculated. These parameters then were used in various ways to evaluate the composition, linearity and stability of the specimens, assess the analytic precision of each laboratory, assess the accuracy of the laboratories relative to their peer group and identify systematic differences among peer groups. The results suggest that this technic is a viable approach to the evaluation of laboratory performance in enzymatic analyses.

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