Total Synthesis of Lucilactaene, A Cell Cycle Inhibitor Active in p53-Inactive Cells
- 27 October 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (46) , 16038-16039
- https://doi.org/10.1021/ja056217g
Abstract
Hetero-bis-metalated 1,3-butadiene is employed in the lynchpin coupling of synthetic fragments of the side chain of the antitumor agent, lucilactaene. Sequential Stille and Suzuki−Miyaura couplings interpolate this unique boron/tin diene into the pentaene chain. The total synthesis of lucilactaene was accomplished efficiently, in just eight linear steps.Keywords
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