Radiosensitivity and Postirradiation Changes of Bone Marrow Clonogenic Stromal Mechanocytes

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Abstract
The in vitro colony assay was used to determine radiosensitivity and post-irradiation changes of guinea pig clonogenic bone marrow stromal fibroblasts (CFU-F). Do [mean lethal dose] of the CFU-F survival curve proved to be about 200 rad, while n is 1.4. Immediately after total-body exposure to 400 rad and to local exposure of tibias to 400 rad, the number of CFU-F diminishes in accordance with Do; it sharply increases after 6 h and then decreases again. In the period between the 8th and 12th day following local irradiation, the number of CFU-F doubled in the course of 30-35 h but later the rate of recovery slowed down. Practically no CFU-F were traced during 3 mo. after local exposure to 2 krad.