Plantar warts recently turned black. Clinical and histopathologic findings

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Abstract
The inflammatory component associated with blackening and subsequent regression of plantar warts has been little apprecitated in the literature. Two patients with plantar warts in whom 1 of the warts showed prominent, clinically evident inflammation were observed. Blackening and subsequent regression of all plantar warts then occurred. In 1 patient, microscopic examination of biopsy specimens of 2 lesions that were taken within 24 and 72 h, respectively, after they had turned black demonstrated the following histologic findings: blood clots and hemorrhage in the stratum corneum, degeneration and necrosis of epidermal cells, eosinophilic cytoplasmic masses within degenerating epidermal cells, thrombosis of superficial and deeper dermal blood vessels, a mononuclear cell infiltrate in and around dermal blood vessels, and a mixed polymorphonuclear and lymphocytic infiltration in the areas of hemorrhage and degenerating epidermis. This constellation of bistopathologic changes suggests that involution was in progress long before blackening of the warts occurred.