Early prenatal diagnosis of congenital toxoplamosis using amniotic fluid samples and tissue culture
- 1 June 1988
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 7 (3) , 423-425
- https://doi.org/10.1007/bf01962355
Abstract
The presence ofToxoplasma gondii in amniotic fluid was demonstrated using tissue culture in four of nine cases of congenital toxoplasmosis, whereasToxoplasma gondii antigen was undetectable using a sensitive enzyme immunoassay technique. Parasites were identified in monolayers four days after inoculation using an indirect immunofluorescence assay. Since tissue culture may provide evidence of infection within a few days, this method is proposed for early prenatal diagnosis of congenital toxoplasmosis.Keywords
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