The Regulation of Decidual Prostaglandin Biosynthesis by Growth Factors, Phorbol Esters, and Calcium1
- 1 May 1991
- journal article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 44 (5) , 871-874
- https://doi.org/10.1095/biolreprod44.5.871
Abstract
The production of prostaglandins by decidua may play a significant part in the mechanisms of human parturition. We have evaluated the regulation of prostaglandin production in human decidual cells in monolayer culture. Both epidermal growth factor and transforming growth factor-alpha induced concentration-related increases in decidual prostaglandin production with significant changes occurring at concentrations of 1 to 10 ng/ml. Two active phorbol esters elicited concentration-related increases in decidual prostaglandin production whereas an inactive phorbol analogue was without effect. The calcium ionophores, ionomycin and A-23187, also stimulated prostaglandin production by human decidual cell cultures. Hence prostaglandin production by human decidua is regulated by hormones and agents in a manner similar to that of other cells including amnion and may play a significant part in the mechanism of parturition.Keywords
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