G sα contains an unidentified covalent modification that increases its affinity for adenylyl cyclase
Open Access
- 10 June 1997
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 94 (12) , 6116-6120
- https://doi.org/10.1073/pnas.94.12.6116
Abstract
Many G protein α subunits are dually acylated with myristate and palmitate or are palmitoylated on more than one cysteine residue near their N termini. The Gα protein that activates adenylyl cyclase, αs, is not myristoylated but can be reversibly palmitoylated. It appears that αs contains another, as-yet-unidentified covalent modification that decreases its apparent dissociation constant for adenylyl cyclase from 50 nM to s does not account for its high affinity for adenylyl cyclase.Keywords
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