Model for the Action of Hemoglobin
- 1 December 1970
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 67 (4) , 1662-1668
- https://doi.org/10.1073/pnas.67.4.1662
Abstract
A model is developed for hemoglobin which depends on six Bohr groups per tetramer of hemoglobin. These six groups are assumed to be located in six regions between the four subunits of hemoglobin. When the Bohr groups are assumed to be perturbed in an asymmetrical manner on binding oxygen, these groups then generate the cooperative interactions of hemoglobin. This approach makes it possible to explain oxygen binding, the Bohr effect, specific salt effects, and aggregation effects in a unified manner.Keywords
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