Liver Changes in Vitamin B12 and Riboflavin-Deficient Rats Before and After Partial Hepatectomy
- 1 August 1954
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 178 (2) , 338-340
- https://doi.org/10.1152/ajplegacy.1954.178.2.338
Abstract
The nucleic acid composition, N, and cell counts of the liver were determined from vit. B12-deficient and supplemented rats subjected to additional stress (partial hepatectomy). Comparable studies were also conducted with riboflavin deficient and supplemented rats. A higher mortality and limited regeneration of liver occurred for the vit. B12-deficient group than the B12-supplemented group or the riboflavin deficient or control groups. The DNA and RNA/g. of liver wt. or liver N was reduced in a vit. B12 deficiency, but not in a riboflavin deficiency. The specific role of vit. B12 in nucleic acid synthesis is emphasized.Keywords
This publication has 2 references indexed in Scilit:
- Effect of Vitamin B12 on Nucleic Acid Metabolism of the RatExperimental Biology and Medicine, 1952
- The Vitamin B12 Requirement of the Syrian Hamster.Experimental Biology and Medicine, 1950