Chronic ethanol ingestion and the hepatocarcinogenicity of N‐hydroxy‐N‐2‐fluorenylacetamide

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Abstract
The effect of long‐term administration of 10% and 20% ethanol solutions on the hepatocarcinogenicity of N‐hydroxy‐N‐2‐fluorenylacetamide in two strains of rats was investigated. In tests with ethanol and carcinogen, started with 4‐ to 6‐week‐old Fischer rats the size of the liver and the extent of tumor formation were slightly less with male rats, and slightly more with females, as compared to rats fed only carcinogen. Experiments beginning with 16‐week‐old males, or with ethanol following carcinogen, were without additional effect. In NIH black rats, less susceptible to carcinogen and with a longer experimental period of 64 weeks, the concurrent intake of 10% ethanol did not affect the liver tumor incidence, although in females there seemed to be fewer cholangiomas and more hepatomas.

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