Serum fibrin/fibrinogen degradation products after experimental pulmonary embolism

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Abstract
Serum fibrin/fibrinogen degradation products (FDP)have been measured for up to 12 hours after pulmonary embolism in 11 anaesthetized dogs. Embolism was produced by the reinjection of 3 ml/kg of clotted autologous blood. Five control animals received a similar volume of injected saline. There was a significant increase in FDP levels in 8 out of 11 animals. The rise appeared within 10 minutes and reached a maximum at 30-60 minutes. High levels were sustained for up to 7 hours. There was considerable individual variation in response. A second embolus 4 hours after the first in 5 animals tended to produce a greater increase in FDP.