Ontogeny of expression of UCHL1 antigen on TcR‐1+ (CD4/8) and TcRδ+ T cells
- 1 April 1989
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 19 (4) , 771-773
- https://doi.org/10.1002/eji.1830190430
Abstract
The frequency of blood mononuclear cells expressing the 180-kDa splice variant of the common leukocyte antigen identified by the UCHL1 monoclonal antibody (a characteristic of post-thymic cells which have been through a cycle of stimulation) rose in a logarithmic relationship to age between birth and 16 years. At birth only a low frequency of CD4+ (negative for CD 25) and no CD8+ T cells expressed UCHL1. The subsequent increase in UCHL1 expression occurred in parallel on T cells expressing α/β receptors and γ/δ receptors, suggesting that these subsets participated in postthymic proliferation in proportion to their numbers in blood. The frequency of UCHL1 expression on CD8 cells was 5–15% less than on CD4 cells.This publication has 14 references indexed in Scilit:
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