Relation of Anaphylaxis to Immunity

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Abstract
Summary and Conclusions: The blood of an actively immunized dog, therefore, contains no antibody that serves as a demonstrable circulating defense to hypersensitize fixed tissues. The immune blood, however, does contain a desensitizing substance, capable of causing complete desensitization of hypersensitive fixed tissues. This desensitization is effected only after a latent period of about forty-eight hours. All phenomena of passive desensitization or passive immunization thus far studied in dogs may be accounted for as a result of the action of this desensitizing antibody. As pointed out in previous papers (2, 4), there is conclusive evidence that in dogs the sensitizing antibody and desensitizing antibody are of different chemical composition, and that neither of these substances is identical with the specific precipitin of our test tube reactions.

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