Inhibition of gastric motility induced by hepatic portal injections of D‐glucose and its anomers.

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Abstract
Intragastric pressures were recorded in bilaterally adrenalectomized male rats with insulin hypoglycemia. A significant depression in intragastric pressure was noted following the administration of D-glucose injected into the hepatic portal vein but not after the administration of L-glucose, D-mannose, D-fructose, D-galactose, D-xylose or D-arabinose. The reduction in intragastric pressure induced by the portal administration of D-glucose was not reproduced following selective division of the hepatic branch of the vagus nerve. Of the 3 anomeric forms of D-glucose used (.alpha.-D-glucose, equilibrated D-glucose and .beta.-D-glucose), .beta.-D-glucose was most potent in reducing the intragastric pressure. Vagal afferents may convey information concerning glucose concentration in the portal vein to the CNS and the activation of such afferents may modulate gastric motility which is dependent on the anomeric stereospecificity of D-glucose.