Sesquiterpene Esters from Celastrus orbiculatus and Their Structure−Activity Relationship on the Modulation of Multidrug Resistance

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Abstract
Six new (1−6) and three known (7−9) sesquiterpene esters were isolated from the roots of Celastrus orbiculatus. The structures of the new compounds were elucidated as 1β-acetoxy-6α-furoyloxy-9α-benzoyloxydihydro-β-agarofuran (1), 1β-acetoxy-6α-benzoyloxy-9α-furoyloxydihydro-β-agarofuran (2), 1β-acetoxy-6α,9α-difuroyloxydihydro-β-agarofuran (3), 1β,2β-diacetoxy-6α-furoyloxy-9α-benzoyloxydihydro-β-agarofuran (4), 1β-acetoxy-2β,6α-difuroyloxy-9α-benzoyloxydihydro-β-agarofuran (5), and 1β-acetoxy-2β,6α,9α-tribenzoyloxydihydro-β-agarofuran (6). Compounds 4, 5, and 7−9 were shown to be more active than verapamil in reversing vinblastine resistance in multidrug-resistant KB-V1 cells.