Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors

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Abstract
The endogenous opioid peptide dynorphin A has non-opioid effects that can damage the spinal cord when given in high doses. Dynorphin has been shown to increase the receptive field size of spinal cord neurons and facilitate C-fiber-evoked reflexes. Furthermore, endogenous dynorphin levels inc

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