Is Red-Cell Creatine Metabolic Garbage?

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Abstract
To the Editor: Recently Valeri and Fortier pointed out an interesting correlation between the 2,3-diphosphoglycerate (2,3-DPG) and creatine content of erythrocytes.1 Red cells are rich in creatine, containing approximately 0.5 mM. Except for glucose, amino acids and electrolytes, only the concentration of hemoglobin (5 mM), 2,3-DPG (5 mM), glutathione (2 mM) and ATP (1.5 mM) exceeds that of creatine in erythrocytes. The function of creatine in red cells, however, is unknown. The observations of Valeri and Fortier suggested that perhaps it might serve as an additional regulator of the oxygen dissociation curve, either by directly affecting the oxygen affinity of . . .

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