Induced Accumulation of Citrate in Therapy of Experimental Lead Poisoning.
- 1 June 1956
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 92 (2) , 331-333
- https://doi.org/10.3181/00379727-92-22468
Abstract
Summary The concept of interference in a metabolic cycle as a means of modifying metal toxicity has been tested. The accumulation of citric acid in certain soft tissues of the rat has been induced by administration of small, non-lethal doses of sodium fluoroacetate. This has been found to give partial protection to rats acutely poisoned with lead nitrate. Of rats given the LD90 of lead nitrate, 53% survived when treated with sodium fluoroacetate. The LD50 of lead nitrate was increased from 58.2 mg/kg (as Pb) in saline controls to 67.7 mg/kg in fluoroacetate-treated rats.Keywords
This publication has 4 references indexed in Scilit:
- The inhibition of aconitase by ‘inhibitor fractions’ isolated from tissues poisoned with fluoroacetateBiochemical Journal, 1952
- A further study of the inhibition of aconitase by ‘inhibitor fraction’ isolated from tissues poisoned with fluoroacetateBiochimica et Biophysica Acta, 1952
- CITRATE FORMATION IN VIVO INDUCED BY NON-LETHAL DOSES OF FLUOROACETATEJournal of Biological Chemistry, 1951
- THE TREATMENT OF LEAD POISONING BY SODIUM CITRATEThe Lancet Healthy Longevity, 1943