IGE SYNTHESIS INVITRO INDUCED BY T-CELL FACTORS FROM PATIENTS WITH ELEVATED SERUM IGE LEVELS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 52  (1) , 85-88
Abstract
The effect of unstimulated T cell culture supernatants (TCS) from patients with atopic dermatitis and high serum IgE levels on the IgE production in vitro by B cell rich suspensions from normal individuals or grass pollen sensitive patients with mild atopy was evaluated. TCS from patients with raised IgE enabled B cell suspensions from normal individuals to produce detectable amounts of IgE and potentiated the spontaneous IgE synthesis in vitro by B cell suspensions from grass sensitive patients. The addition of TCS from normal subjects with low serum IgE levels did not increase or even reduced IgE synthesis by B cell cultures. When the same B cell cultures were analyzed for their ability to produce IgG or IgM protein, no significant differences were observed. T lymphocytes from patients with high serum IgE levels can apparently release soluble factor(s) possessing isotype (IgE) specific potentiating activity.