THE EFFECT OF CORTISONE ACETATE ON THE PRODUCTION OF CIRCULATING HEMOLYTIC ANTIBODIES IN THE MOUSE
- 1 January 1954
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 32 (1) , 372-382
- https://doi.org/10.1139/y54-040
Abstract
Quantitative immunochemical methods have been used to show that in the mouse cortisone acetate suppresses the formation of circulating hemolytic antibodies to sheep erythrocytes. The amount of suppression varies with the dose of both cortisone acetate and antigen. Experimental conditions are defined whereby an almost complete inhibition of circulating antibody occurs. The method serves as a quantitative procedure for comparing the effect of different steroids and hormones on antibody production as well as a means of studying possible cortisone antagonists.Keywords
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