MouseZic1Is Involved in Cerebellar Development
Open Access
- 1 January 1998
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 18 (1) , 284-293
- https://doi.org/10.1523/jneurosci.18-01-00284.1998
Abstract
Zicgenes encode zinc finger proteins, the expression of which is highly restricted to cerebellar granule cells and their precursors. These genes are homologs of theDrosophilapair-rule geneodd-paired. To clarify the role of theZic1gene, we have generated mice deficient inZic1. Homozygous mice showed remarkable ataxia during postnatal development. Nearly all of the mice died within 1 month. Their cerebella were hypoplastic and missing a lobule in the anterior lobe. A bromodeoxyuridine labeling study indicated a reduction both in the proliferating cell fraction in the external germinal layer (EGL), from 14 d postcoitum, and in forward movement of the EGL. These findings suggest thatZic1may determine the cerebellar folial pattern principally via regulation of cell proliferation in the EGL.Keywords
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