Induction of Lung Tumors in RFM Mice after Localized Exposures to X Rays or Neutrons

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Abstract
Dose-response relationships were compared for the induction of lung tumors in RFM mice after localized thoracic exposures to X-rays or fission neutrons. Animals were killed 9 mo. after localized irradiation, their lungs were cleared and the tumors counted to determine percentage incidence and tumors per mouse. The relationship between tumors per mouse and X-ray dose could be described adequately by a linear-quadratic model with a shallow initial slope, or by a threshold model with a dose-squared response above the threshold dose, linearity could be rejected over the dose range of 0-900 rad. For neutrons the relationship between tumors per mouse and dose over the range of 0-25 rad could be described by a linear, or a threshold model with linear response above the threshold. In either case, the relative biological effectiveness increased with decreasing neutron dose from 25 at 25 rad to 40 at 10 rad.

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