Dynamic response of adhesion complexes: Beyond the single-path picture
- 10 May 2002
- journal article
- Published by American Physical Society (APS) in Physical Review E
- Vol. 65 (5) , 051910
- https://doi.org/10.1103/physreve.65.051910
Abstract
4 pages, 6 figuresWe analyze the response of molecular adhesion complexes to increasing pulling forces (dynamic force spectroscopy) when dissociation can occur along either one of two alternative trajectories in the underlying multidimensional energy landscape. A great diversity of behaviors (e.g. non-monotonicity) is found for the unbinding force and time as a function of the rate at which the pulling force is increased. We highlight an intrinsic difficulty in unambiguously determining the features of the energy landscape from single-molecule pulling experiments. We also suggest a class of ``harpoon\'\' stickers that bind easily but resist strong pulling efficientlyKeywords
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This publication has 19 references indexed in Scilit:
- Probing the Relation Between Force—Lifetime—and Chemistry in Single Molecular BondsAnnual Review of Biophysics, 2001
- Free energy reconstruction from nonequilibrium single-molecule pulling experimentsProceedings of the National Academy of Sciences, 2001
- Probing Chromosome Structure with Dynamic Force RelaxationPhysical Review Letters, 2001
- Characterization of Single Actomyosin Rigor Bonds: Load Dependence of Lifetime and Mechanical PropertiesBiophysical Journal, 2000
- Dynamic Force Spectroscopy of Molecular Adhesion BondsPhysical Review Letters, 2000
- Rupture of Multiple Parallel Molecular Bonds under Dynamic LoadingPhysical Review Letters, 2000
- Statistical Breakage of Single Protein A-IgG Bonds Reveals Crossover from Spontaneous to Force-Induced Bond DissociationPhysical Review Letters, 1999
- Energy landscapes of receptor–ligand bonds explored with dynamic force spectroscopyNature, 1999
- Introductory Lecture Energy landscapes of biomolecular adhesion and receptor anchoring at interfaces explored with dynamic force spectroscopyFaraday Discussions, 1999
- Dynamic strength of molecular adhesion bondsBiophysical Journal, 1997