Effect of Exercise and Thermal Stress on Subcutaneous Protein Transport

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Abstract
Radioiodinated albumin was injected into the s.c. tissue of the thigh of human subjects and its disappearance rate from the injection site and the blood levels of the tracer were compared between exercise loaded, heat loaded experiments and the control utilizing two-compartment analysis. The time course of radioactivity in the blood was expressed as the equation p(t) = A(e-.alpha.t - e-.beta.t). In the exercise experiment, the half-time of .beta. and the time required to reach the maximum level was significantly shorter than in the heat experiment and in the controls. The decay of radioactivity at the injection site was set to the equation s(t) = Be-.gamma.t + Ce-.delta.t by the least square method. The value of .gamma., which had a half-time of about 24 h, was significantly shorter in the exercise than in the control experiments. The rate of mobilization of subcutaneous protein via lymph flow is faster under an exercise load than the control, and the rate under heat load does not deviate from control experiments.

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